On September 1, 1858 a mob burned down this hospital in protest of its close vicinity to their homes. With patients infected with diseases such as smallpox, cholera, typhus and yellow fever, Staten Island residents feared catching these deadly ailments. In burning down the quarantine hospital, they felt they could close the operation completely. The night of the mob, only a mob member and yellow fever patient died. The next day, the mob returned to burn down the remaining buildings that survived.Although yellow fever continued to appear annually following this second epidemic sized outbreak, the final large yellow fever outbreak in New York City occurred in 1803. Following this year, the vengeful fever would fade away. However, in 1805, another 270 people died from the disease in New York. America’s last yellow fever epidemic occurred in New Orleans in 1905 and took 900 lives.