John Tyler's presidency began under challenging circumstances. Ascending to office after William Henry Harrison's sudden death, Tyler faced criticism as "His Accidency." He clashed with the Whigs, who had nominated him for vice president to gain southern support, leading to his expulsion from the party after vetoing their bills. His Cabinet resigned, except for Secretary of State Daniel Webster, and Democrats distanced themselves. Personal tragedy struck with the death of his wife, Letitia, in 1842, leaving him politically isolated and personally bereaved.